Figure 3.

SVs associated with recurrent translocations, copy-number changes, and altered gene expression. A, Relative contribution (y-axis) of simple and complex SV classes to canonical translocations (TRA) involving IGH as well as translocations of MYC with canonical and noncanonical partners (x-axis). “Non-IG” includes MYC translocations that do not involve IGH, IGL, or IGK. B, Gene expression of canonical and noncanonical partners of translocations involving IGH (left), either light chain gene locus (center), or MYC (right). Each point represents a sample, colored by the translocation class involved or absence of a translocation (gray). Boxplots shows the median and IQR of expression across all patients, with whiskers extending to 1.5 * IQR. The templated insertion of IGH and MAF with low expression was part of a multichromosomal event involving and causing the overexpression of CCND1. TPM, trancripts per million. C, Structural basis of established multiple myeloma CNA drivers, showing the relative contribution of whole-arm events and CNAs associated with a specific SV. Intrachromosomal events without a clear causal SV were classified as “unknown” (7% of CNAs overall). D, Impact of copy number and SV involvement on normalized gene expression values (Z-scores), estimated by multivariate linear regression. Estimates with 95% CI for each parameter are shown. Pooled analysis was performed for all expressed genes on autosomes across all patients, excluding structural events involving immunoglobulin loci.