Figure 7.

Two or more putative driver alterations caused by a single SV. Putative driver alterations recurrently involved by multi-driver events (involved in 5 or more patients). A, Number of multidriver events involving each gene colored by the SV class responsible. B, Heatmap showing the number of times each pair of putative drivers co-occurs. Co-occurrence was defined by at least two drivers on different chromosomal copy-number segments caused by the same event. Axis legends are colored according to the gain-of-function (blue) or loss-of-function (red) status of each driver.