Figure 2.

Scheme of leukemic hematopoiesis. Cells develop from HSCs to pre–pro-B cells and acquire genetic lesions during these stages. It is not clear at what stage each of the mutations actually occurs. Common mutations of hematopoietic TFs are shown on light green background. These mutations lead to the formation of preleukemic clones. Without a second mutagenic event, normal hematopoiesis will be sustained. In case of a secondary oncogenic event, probably triggered by an environmental factor, B-ALL arises.