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. 2020 Dec 31;15(12):e0240873. doi: 10.1371/journal.pone.0240873

Table 3. Target genes in 12 signaling pathways enrichment related to T2DM.

KEGG ID Target genes False Discovery Rate
hsa04933:AGE-RAGE signaling pathway in diabetic complications AKT1,NFKB1,PRKCA,PRKCE 0.0075
hsa04920:Adipocytokine signaling pathway AKT1,PPARA,NFKB1 0.0208
hsa04917:Prolactin signaling pathway ESR1,ESR2,AKT1,NFKB1,CYP17A1 0.00031
hsa04915:Estrogen signaling pathway AKT1,GABBR1,ESR1,PGR,ESR2 0.0028
hsa04664:Fc epsilon RI signaling pathway AKT1,ALOX5,PLA2G4A,PRKCA 0.0021
hsa04660:T cell receptor signaling pathway AKT1,NFKB1,PTPRC 0.0408
hsa04370:VEGF signaling pathway AKT1,PRKCA,PLA2G4A 0.0155
hsa04152:AMPK signaling pathway AKT1,HNF4A,PPARG,HMGCR 0.013
hsa04071:Sphingolipid signaling pathway ADORA1,S1PR1,AKT1,NFKB1,PRKCA,PRKCE 0.00029
hsa04021:cAMP signaling pathway ADORA1,GABBR1,AKT1,PTGER3,PPARA,NFKB1 0.0022
hsa03320:PPAR signaling pathway FABP3,FABP4,NR1H3,PPARA,PPARD,PPARG 0.0000419
hsa04066:HIF-1 signaling pathway GAPDH,AKT1,NFKB1,PRKCA 0.0075