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. 2020 Dec 31;15(12):e0244457. doi: 10.1371/journal.pone.0244457

Table 3. Factors associated with false-negative RDT results using PCR as a reference.

Variable RDT-/PCR+/False-negative Univariable Multivariable
n (%) OR (95% CI) p-value aOR (95% CI) p-value
Age (year)
 ≥5 108 (55.7) 1 (Reference) 0.179 1 (Reference)
 <5 87 (63.0) 1.36 (0.87–2.13) 1.35 (0.83–2.19) 0.224
Parasite density (μL)
 ≥1000 105 (51.0) 1 (Reference) 1 (Reference)
 <1000 90 (71.4) 2.4 (1.51–3.89) 0.001 2.65(1.62–4.38) 0.001
Gene deletion
 No deletion 171 (56.4) 1 (Reference) 1 (Reference)
pfhrp 2/3 deletion 24 (82.8) 3.71 (1.49–11.23) 0.01 4.4 (1.72–13.66) 0.004
Parasite species
P. falciparum 165 (55.0) 1 (Reference) 1 (Reference)
 Non-P. falciparum 37.0 (93.9) 12.76 (3.77–79.7) 0.001 18.65 (5.3–118.71) 0.001
Endemicity
 Moderate 63 (61.2) 1 (Reference) 1 (Reference)
 Low 132 (57.6) 1.16 (0.72–1.87) 0.547 1.19 (0.63–2.24) 0.595
Region
 Western 95 (57.6) 1 (Reference) 1 (Reference)
 Eastern 100 (59.9) 0.91 (0.59–1.41) 0.67 0.83 (0.45–1.5) 0.527

OR = unadjusted odds ratio, aOR = adjusted odds ratio.