TABLE 1.

Classification of Alzheimer's disease (AD) related targets.

Classification of target	Targets
Cholinergic system dysfunction	ACHE, BCHE, CHRM1, CHRM2, CHRNA4, CHRNA7
Glutamate/GABA system dysfunction	GRIA1, GRIA2, GABRG1, GABBR1, GRM2, GRM3, GRIN1
Aggregates of amyloid-β peptide	APP, BACE1, PSEN1
Hyper-phosphorylated tau	HSP90AA1, CDK5, GSK3B, MAPT, PIN1
Serotonergic system dysfunction	HTR1A, HTR2A, HTR3A, HTR4, HTR6
Oxidative stress	MAOB, MPO, PDE4A, PDE4B, PDE9A
Neuroinflammation	MAPK8, MAPK9, MAPK10, MAPKAPK3, CHUK, IKBKB, NOS2, PPARG, TNF, ADORA2A, ALOX12, PTGS2
Mitochondrial dysfunction	PPID, PDHX
Other	ACAT1, COMT, ESR1, HRH3, HMGCS1, IDE, SIGMAR1