TABLE 2.

Target distribution of potential active constituents.

No.	Targets	Abbreviation	The number of active constituents
1	cyclooxygenase-2	PTGS2	809
2	estrogen receptor α	ESR1	558
3	acetylcholinesterase	ACHE	425
4	β-secreatase	BACE1	266
5	12-lipoxygenase	ALOX12	227
6	gamma-aminobutyric acid A receptor	GABRG1	182
7	tumor necrosis factor alpha	TNF	162
8	Monoamine oxidase B	MAOB	161
9	glycogen synthase kinase 3 beta	GSK3B	152
10	A2A adenosine receptor	ADORA2A	145
11	beta-amyloid precursor protein	APP	109
12	microtubule-associated protein tau	MAPT	71
13	inducible nitric oxide synthase	NOS2	63
14	Cholesterol Acyltransferase	ACAT1	37
15	metabotropic glutamate receptor 2	GRM2	35
16	5 Hydroxytryptamine 1A receptor	HTR1A	29
17	cyclin-dependent kinase 5	CDK5	21
18	phosphodiesterase type 4B	PDE4B	19
19	5 Hydroxytryptamine 3A receptor	HTR3A	18
20	butyrylcholinesterase	BCHE	16
21	nicotinic acetylcholine receptor α7	CHRNA7	15
22	5 Hydroxytryptamine 4 receptor	HTR4	13
23	c-Jun N-terminal kinase-3	MAPK10	11
24	muscarnic m2 receptor	CHRM2	11
25	3-hydroxy-3-methyl glutaryl coenzyme- A reductase	HMGCS1	9
26	5 Hydroxytryptamine 2A receptor	HTR2A	8
27	5 Hydroxytryptamine 6 receptor	HTR6	8
28	catechol O-methyltransferase	COMT	7
29	phosphodiesterase type 4A	PDE4A	7
30	muscarnic m1 receptor	CHRM1	6
31	heat shock protein 90	HSP90AA1	5
32	Peroxisome proliferator-activated receptor gamma	PPARG	5
33	sigma-1 receptor	SIGMAR1	5
34	nuclear factor kappa-B kinase beta	IKBKB	4
35	N-methyl-D-aspartate receptor	GRIN1	4
36	insulin-degrading enzyme	IDE	3
37	peptidyl prolyl cis/trans Isomerases	PIN1	2
38	c-Jun N-terminal kinase-1	MAPK8	1
39	histamine H3 receptor	HRH3	1
40	nicotinic acetylcholine receptor α4	CHRNA4	1
41	Cyclophilin D	PPID	1