Immunologic response was defined as a 25% increase in CD4 cell counts (A) or reaching a CD4 cell count ≥750 cells/μL (B). Models were adjusted for age (per ten years older), ethnicity, mode of transmission, baseline date (per year later), baseline smoking status, hypertension, diabetes, HBV and HCV status, prior AIDS event, cardiovascular disease, chronic kidney disease, end stage liver disease, non-AIDS-defining malignancies and prior fractures, viral load (<200 cp/mL, ≥200 cp/mL at baseline) and treatment status, CD4 count (nadir and baseline; both per 100 cells higher), treatment regimen and number of drugs in regimen. *Excluding individuals with a CD4 cell count ≥750 cells/μL at baseline.