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. 2020 Dec 31;15(12):e0243625. doi: 10.1371/journal.pone.0243625

Fig 6. Adjusted odds ratios of cTO success, on-treatment success and favorable immunologic outcomes at 12 ± 3 months for ART-naïve individuals initiating treatment after 16th January 2014.

Fig 6

Forest plots showing the aOR of cTO success, on-treatment success, and immunologic response as a 25% increase in CD4 cell counts or reaching a CD4 cell count ≥750 cells/μL. A controlled viral load was defined as <200 cp/mL. Multivariable models were adjusted for age (per ten years older), ethnicity, mode of transmission, baseline date (per year later), baseline smoking status, hypertension, diabetes, HBV and HCV status, prior AIDS event, cardiovascular disease, chronic kidney disease, end stage liver disease, non-AIDS-defining malignancies and prior fractures, viral load (<200 cp/mL, ≥200 cp/mL at baseline), CD4 count (nadir and baseline; both per 100 cells higher, treatment regimen and number of drugs in regimen. *cTO failure was defined as ≥1 either of VL ≥200 cp/mL, unknown VL, ART regimen change, AIDS events, or death. ** Individuals with known VL at 12±3 months without ART regimen change in the period. ***Excluding individuals with ≥750 CD4 cells/μL at baseline.