Table 4. The incidence of adverse drug reactions caused by prophylactic INH.

	Number of cases a	Incidence rate (95% CI) b
Mild-to-moderate adverse drug reactions	85	110.4 (88.2 to 136.5)
AST/ALT elevation	31	40.3 (27.4 to 57.2)
Peripheral neuropathy	26	33.8 (22.1 to 49.5)
GI discomfort	10	13.0 (6.2 to 23.9)
Skin rash	6	7.8 (2.9 to 17.0)
Thrombocytopenia	5	6.5 (2.1 to 15.2)
Anemia	1	1.3 (0.03 to 7.2)
Leukopenia	1	1.3 (0.03 to 7.2)
Anorexia	2	2.6 (0.3 to 9.4)
Others c	3	3.9 (0.8 to 11.4)
Severe adverse drug reactions d	1	1.3 (0.03 to 7.2)
Fulminant hepatitis	1	1.3 (0.03 to 7.2)

ALT, alanine aminotransferase; AST, aspartate aminotransferase; CI, confidence interval; GI, gastrointestinal; INH, isoniazid; NA, not applicable.

^a The total observation period was 77.0 person-years for 152 episodes.

^b Rate per 100 person-years.

^c Including eosinophilia (n = 1), pruritus (n = 1), and general weakness (n = 1).

^d Occurred in the high-risk subgroup.