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. 2020 Dec 31;15(12):e0244792. doi: 10.1371/journal.pone.0244792

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© 2020 Oyama et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 4 — (A) Platelet-rich plasma (PRP) was obtained from human healthy volunteers. Aggregation was induced with 1 μl/ml collagen and recorded as the percent change in light transmission using an aggregometer. (B) Healthy human volunteers were exposed to 30 minutes of intense light (10,000 Lux) at 8:30 AM on 5 consecutive days. A blood draw was performed before light exposure on the first day (8:30 AM) and 3 or 5 days after light exposure (9.00 AM). Plasma samples were analyzed using the SOMAscan platform. (C) Reactome analysis of intense light-regulated proteins. (D) Ingenuity analysis of intense light-regulated proteins. (E) All light-regulated proteins affecting coagulation (n = 3 individual subjects, n = 12 of total samples/arrays).