Table 2. Pooled data of clinical indicators.
| Outcomes (TNFi vs. Control) | Study number | Total patient number | Heterogeneity | MD (95%CI) | P value | ||
|---|---|---|---|---|---|---|---|
| TNFi | Control | I2 | P | ||||
| ASDAS | 7 | 367 | 364 | 82% | P<0.00001 | 0.96[0.71, 1.20] | P<0.00001* |
| BASDAI | 7 | 508 | 505 | 77% | 0.0002 | 1.05[0.61, 1.49] | P<0.00001* |
| BASFI | 6 | 485 | 482 | 52% | 0.06 | 0.88[0.56, 1.19] | P<0.00001* |
| CRP | 7 | 503 | 499 | 66% | 0.007 | 3.87[1.09, 6.65] | P = 0.006* |
Abbreviations: TNFi, tumor necrosis factor α inhibitor; ASDAS, Ankylosing Spondylitis Disease Activity Score; BASDAI, Bath Ankylosing Spondylitis disease activity index; BASFI, Bath Ankylosing Spondylitis functional index; CRP, C-reactive protein; MD, mean difference; CI, confidence interval;
*p<0.05.