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. 2020 Dec 31;15(12):e0244861. doi: 10.1371/journal.pone.0244861

Table 2. Tabulated compositions and calculated ρe by imaging for synthetic tissue phantoms.

Tissue Type Water (%) Lipid (%) Protein (%) Minerals (%) ρ (g/cc) ρe ρ(kV1) ρe(kV1) ρ(kV5) ρe(kV5) ρ(MV1) ρe(MV1) ρ(MV5) ρe(MV5)
Skin 75 0 25 0 1.060 ± 0.002 1.048 ± 0.002 1.052 1.033 1.053 1.042 1.065 1.045 1.068 1.057
(-0.7%) (-1.4%) (-0.6%) (-0.5%) (0.5%) (-0.3%) (0.8%) (0.8%)
Muscle 75 5 20 0 1.045 ± 0.002 1.036 ± 0.002 1.034 1.017 1.035 1.027 1.051 1.032 1.051 1.042
(-1.0%) (-1.9%) (-0.9%) (-0.9%) (0.6%) (-0.4%) (0.6%) (0.6%)
Adipose 47 49 4 0 0.953 ± 0.002 0.955 ± 0.002 0.941 0.931 0.946 0.947 0.970 0.958 0.960 0.961
(-1.2%) (-2.5%) (-0.7%) (-0.9%) (1.8%) (0.3%) (0.7%) (0.6%)
Spongiosa 27 47 13 13 1.060 ± 0.002 1.044 ± 0.002 1.099 1.071 1.065 1.046 1.055 1.036 1.059 1.041
(3.6%) (2.6%) (0.4%) (0.2%) (-0.4%) (-0.8%) (-0.1%) (-0.3%)

Ground truth ρ and ρe values were calculated with noted uncertainties and used as a basis of comparison for the two other methods of calculating ρ and ρe by imaging. For ρ and ρe by imaging (either kV or MV CT), two methods were used in its determination: 1) piecewise linear (1-dimensional) direct interpolation of HU from CIRS tissue surrogate phantom imaging data (kV1/MV1) and 2) calculation by HU and known molecular composition (water, lipid, protein, and minerals) (kV5/MV5). Errors compared with ground truth for each imaging determined value of ρ and ρe are shown in parentheses.