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. 2020 Dec 17;14(12):e0008951. doi: 10.1371/journal.pntd.0008951

Table 2. KEGG pathway enrichment analysis.

Pathways DEmiRNA-targeted gene pair number DEmiRNA number
1 wpe 4 wpe 12 wpe 1 wpe 4 wpe 12 wpe
Up Down Up Down Up Down Up Down Up Down Up Down
Neural activity-related pathways
    Glutamatergic synapse 1 6 1 13 0 1 1 3 1 5 0 1
    Morphine addiction 1 5 0 10 0 0 1 3 0 3 0 0
    Cocaine addiction 0 3 1 6 0 1 0 1 1 3 0 1
    Cholinergic synapse 1 2 0 16 1 2 1 2 0 5 1 2
    Axon guidance 1 3 0 11 1 1 1 2 0 5 1 1
    Long-term depression 0 2 0 11 0 0 0 1 0 3 0 0
    Serotonergic synapse 1 3 0 13 0 0 1 2 0 4 0 0
    Neuroactive ligand-receptor interaction 0 5 2 18 0 1 0 2 2 2 0 1
    GABAergic synapse 1 3 0 7 0 0 1 3 0 3 0 0
    Circadian entrainment 1 3 1 12 0 2 1 2 1 4 0 1
    Dopaminergic synapse 1 4 0 15 1 3 1 3 0 4 1 2
    Nicotine addiction 0 1 1 1 0 1 0 1 1 1 0 1
    Amphetamine addiction 0 1 1 6 0 2 0 1 1 2 0 1
    Nicotinate and nicotinamide metabolism 0 0 0 3 0 0 0 0 0 1 0 0
    Neurotrophin signaling pathway 0 0 0 10 1 2 0 0 0 4 1 2
Digestion-related pathways
    Bile secretion 0 1 0 6 0 0 0 1 0 2 0 0
    Insulin secretion 0 2 0 10 0 1 0 1 0 1 0 1
    Insulin signaling pathway 0 1 1 9 1 1 0 1 1 5 1 1
    Gastric acid secretion 0 2 0 12 0 1 0 1 0 2 0 1
    Salivary secretion 0 3 0 11 0 0 0 1 0 2 0 0
    Pancreatic secretion 0 3 0 11 0 0 0 1 0 3 0 0
Immune response-related pathways
    Lysosome 1 3 4 14 0 0 1 2 3 4 0 0
    Platelet activation 0 2 1 14 1 1 0 1 1 3 1 1
    Cytokine-cytokine receptor interaction 0 1 0 13 0 0 0 1 0 2 0 0
     Toll-like receptor signaling pathway 0 3 0 12 1 1 0 3 0 5 1 1
    Wnt signaling pathway 0 2 0 12 0 1 0 2 0 3 0 1
    Inflammatory mediator regulation of TRP channels 0 2 0 11 0 1 0 1 0 2 0 1
    Chemokine signaling pathway 1 2 0 10 1 1 1 2 0 4 1 1
    Leukocyte transendothelial migration 0 2 2 7 0 1 0 1 2 2 0 1
    NF-kappa B signaling pathway 0 1 0 9 0 0 0 1 0 3 0 0
    Natural killer cell mediated cytotoxicity 0 0 1 7 0 1 0 0 1 3 0 1
    Fc gamma R-mediated phagocytosis 0 1 2 5 1 1 0 1 2 3 1 1
    T cell receptor signaling pathway 0 0 0 7 1 1 0 0 0 3 1 1
    NOD-like receptor signaling pathway 0 1 0 6 0 1 0 1 0 3 0 1
    Apoptosis 0 1 0 6 1 1 0 1 0 1 1 1
    Ubiquitin mediated proteolysis 1 0 2 4 1 0 1 0 2 3 1 0
    Jak-STAT signaling pathway 0 0 0 6 1 1 0 0 0 1 1 1
    Primary immunodeficiency 0 2 0 5 0 0 0 2 0 1 0 0
    Antigen processing and presentation 0 1 0 5 0 0 0 1 0 1 0 0
    B cell receptor signaling pathway 0 0 0 4 1 1 0 0 0 3 1 1
    Intestinal immune network for IgA production 0 1 0 1 0 0 0 1 0 1 0 0
Cancer-related pathways
    Basal cell carcinoma 0 2 0 6 0 0 0 2 0 3 0 0
    Transcriptional misregulation in cancer 0 2 1 11 0 1 0 2 1 2 0 1
    Proteoglycans in cancer 1 2 0 17 2 2 1 2 0 4 2 2
    Viral carcinogenesis 0 2 3 13 0 0 0 2 3 3 0 0
    Pathways in cancer 0 3 0 26 1 1 0 3 0 5 1 1
    Bladder cancer 0 0 0 5 0 0 0 0 0 3 0 0
    Acute myeloid leukemia 0 0 0 6 1 1 0 0 0 3 1 1
    Thyroid cancer 0 0 0 3 0 0 0 0 0 2 0 0
    Endometrial cancer 0 0 0 4 1 1 0 0 0 3 1 1
    Chronic myeloid leukemia 0 0 0 5 1 1 0 0 0 3 1 1
    Non-small cell lung cancer 0 0 0 4 1 1 0 0 0 3 1 1
    Pancreatic cancer 0 0 0 4 1 1 0 0 0 4 1 1
    Small cell lung cancer 0 0 0 3 1 1 0 0 0 2 1 1
    Renal cell carcinoma 0 0 0 3 1 1 0 0 0 3 1 1
    MicroRNAs in cancer 1 0 0 6 0 0 1 0 0 3 0 0
    Colorectal cancer 0 0 0 4 1 1 0 0 0 3 1 1
    Prostate cancer 0 0 0 9 1 1 0 0 0 4 1 1