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Urease inhibition (IC50) values of synthesized derivatives 4a–l.
| Compound | Urease (jack bean) inhibition IC50 ± SD (nM) |
|---|---|
| 4a | 57.1 ± 1.9 |
| 4b | 1.6 ± 0.2 |
| 4c | 18.2 ± 0.6 |
| 4d | 3.8 ± 0.2 |
| 4e | 62.7 ± 2.1 |
| 4f | 31.2 ± 1.1 |
| 4g | 3.8 ± 0.2 |
| 4h | 4.5 ± 0.2 |
| 4i | 21.1 ± 0.7 |
| 4j | 2.1 ± 0.1 |
| 4k | 50.1 ± 1.7 |
| 4l | 11.5 ± 3.9 |
| Thiourea | 472.1 ± 135.1 |
