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Assessing gcWGAN designs targeting a completely novel fold when the oracle gives feedback on the closest basis fold a.188. (a) TM-score distribution. (b) Best gcWGAN design (not filtered) (blue) and the ground truth (gray) (TM-score = 0.45). (c) Best gcWGAN design (oracle-filtered) (TM-score = 0.46). (d) Sequence diversity (more with lower identity). (e) Sequence novelty (more with lower identity).
