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. 2020 Dec 18;14:577525. doi: 10.3389/fncel.2020.577525

Figure 4.

Figure 4

In the three-chamber assay testing social preference during a 10 min (600 s) observation period, the sniffing time is longer with a stranger mouse (S) than with an empty cage (O) in WT mice, an effect that is lost in constitutive PV+/− mice (red bars). The preference for S is restored by upregulation of parvalbumin (PV) induced by E2 treatment (green bars). Data for the first three groups were previously reported (Filice et al., 2018). The preference for S is attenuated in shPV mice, in which PV is downregulated by isopropyl-β-d-thiogalactoside (IPTG) from PND18–24 (orange bars). Data for IPTG-treated shPV mice is original. All mice were tested at PND25. In the same shPV mice without IPTG treatment (sham-treated), the preference for S is similar to that of WT mice (data not shown). Data for the first three groups are from Filice et al. (2018). All other experimental details on breeding, testing, and data analysis can be found in Filice et al. (2018) and Wöhr et al. (2015). *Represents a significant preference for S over O. **p < 0.01, ***p < 0.001; n.s., not significant.