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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Am J Transplant. 2020 Jul 5:10.1111/ajt.16148. doi: 10.1111/ajt.16148

FIGURE 1.

FIGURE 1

Fibrin(ogen)-rich microvascular plugs are present after normothermic machine perfusion (NMP). Representative images from biopsies of perfused human kidneys 30 min after the start of NMP in A, H&E stained samples (white arrows) and B, transmission electron microscopy samples showing microvascular obstructions with a rouleaux-like aggregation of red blood cells (RBCs). C, Fluorescent staining depicts co-localization of fibrin(ogen) (red) with vasculature (white Ulex stain). Nuclei are stained blue. D, Martius scarlet blue (MSB) stained samples (red—fibrin[ogen]; yellow—RBC) showing obstructions in both glomeruli (top) and microvessels (bottom). Scale bars represent 100 μm unless otherwise noted.