Table 2.
Comparison of distension-induced contractility and pressurization parameters between high resolution manometry (HRM) achalasia subtypes.
| Training cohort; n = 140 | HRM subtype | |||
|---|---|---|---|---|
| Type I achalasia | Type II achalasia | Type III achalasia | P-value | |
| FLIP contractile response pattern, n (%) | ||||
| Absent contractile response | 22 (76) | 26 (32) | 0 | <0.001 |
| Contractility without RRCs | 5 (17) | 34 (42) | 12 (40) | 0.054 |
| RRCs | 2 (7) | 21 (26) | 18 (60) | <0.001 |
| Occluding contractions, n (%) | 4 (14) | 22 (27) | 22 (73) | <0.001 |
| SOCs present, n (%) | 0 | 5 (6) | 13 (43) | <0.001 |
| LES-lift present, n (%) | 1 | 7 (9) | 4 (13) | <0.001 |
| Intra-balloon Pressure - 40ml, mmHg, Median (IQR) | 11 (7 – 20) | 16 (12 – 25) | 29 (22 – 37) | <0.001 |
| Intra-balloon Pressure - 50ml, mmHg, Median (IQR) | 16 (11 – 22) | 21 (15 – 31) | 41 (33 – 52) | <0.001 |
| Intra-balloon Pressure - 60ml, mmHg, Median (IQR) | 20 (18 – 30) | 31 (24 – 43) | 56 ( 42 – 66) | <0.001 |
| Pressure changes > 10mmHg, n (%) | 6 (21) | 41 (51) | 27 (90) | <0.001 |
| Test cohort; n = 40 | HRM subtype | |||
| Type I achalasia | Type II achalasia | Type III achalasia | P-value | |
| FLIP contractile response pattern, n (%) | ||||
| Absent contractile response | 9 (82) | 11 (55) | 1 (5) | 0.002 |
| Contractility without RRCs | 2 (18) | 7 (35) | 3 (27) | 0.485 |
| RRCs | 0 | 0 | 6 (55) | <0.001 |
| Occluding contractions, n (%) | 1 (13) | 1 (6) | 6 (55) | 0.003 |
| SOCs present, n (%) | 1 (9) | 0 | 3 (27) | 0.040 |
| LES-lift present, n (%) | 1 (9) | 2 (11) | 6 (55) | 0.011 |
| Intra-balloon Pressure - 40ml, mmHg, Median (IQR) | 15 (12 – 22) | 15 (12 – 20) | 26 (22 – 33) | <0.001 |
| Intra-balloon Pressure - 50ml, mmHg, Median (IQR) | 19 (15 – 24) | 17 (13 – 22) | 37 (28 – 49) | 0.002 |
| Intra-balloon Pressure - 60ml, mmHg, Median (IQR) | 25 (23 – 30) | 23 (18 – 31) | 42 (36 – 58) | <0.001 |
| Pressure changes > 10mmHg, n (%) | 2 (18) | 4 (22) | 8 (73) | 0.008 |
Percentages indicate percent within HRM subtype. Comparisons are between achalasia subtypes within each cohort. RRC – repetitive retrograde contractions. SOC – sustained occluding contraction. LES – lower esophageal sphincter.