. Author manuscript; available in PMC: 2022 Jan 1.

Published in final edited form as: Histopathology. 2020 Sep 14;78(2):252–264. doi: 10.1111/his.14211

Table 3.

Cause-specific analysis of recurrence-free survival

	Univariate analysis	Multivariate analysis
	P	HR (95% CI)	P
Age	0.0979	1.029 (1.009 – 1.049)	0.0045
Gender	0.2260
History of prior malignancy	0.0365
Tumour grade	0.7892
Tumour location	0.9962
Tumour budding	0.0006
Intra-epithelial tumour-infiltrating lymphocytes	0.0068		0.0348
Yes		1
No		1.862 (1.045–3.316)
Desmoplastic reaction	< 0.0001		< 0.0001
Immature/myxoid		3.382 (1.861–3.316)
Intermediate		0.888 (0.461–1.712)
Mature		1
Lymphovascular invasion	< 0.0001
Perineural invasion	0.0036
Tumour deposits	< 0.0001
MMR expression	0.8230
pT stage	< 0.0001
pN stage	< 0.0001
pTNM prognostic group	< 0.0001		< 0.0001
I		0.159 (0.055–0.457)
II		0.355 (0.203–0.620)
III		1

HR, hazard ratio; CI, confidence interval; pT, pathological T category; pTNM, pathological tumour–node–metastasis; MMR, mismatch repair protein.

Bold indicates statistical significance.