Skip to main content
. 2020 Dec 18;11:607957. doi: 10.3389/fimmu.2020.607957

Figure 1.

Figure 1

M. bovis BCG increases en face aorta atherosclerosis by 8 and 16 weeks post-challenge. (A) Twelve-week old male Ldlr-/- mice were inoculated with M. bovis BCG (0.3–3.0x106 CFU) via the intranasal route. Mice were fed a western-type diet for up to 16 weeks. Age-matched uninfected Ldlr -/- mice fed with an identical diet served as controls. (B) Atherosclerotic lesions in en face aorta were examined using Oil Red O staining at weeks 8 and 16. Data are representative of the aortae of one M. bovis BCG-infected mouse and one control mouse at 16 weeks. (C) Plaque burden was quantified by the plaque size per aorta ratio in M. bovis BCG-infected (blue) and control mice (black). Data are mean ± SD. n = 20 mice per group pooled from 2 independent experiments. Significance was determined by Student’s t-test. *p < 0.05; ***p < 0.001.