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. 2020 Dec 18;11:614256. doi: 10.3389/fimmu.2020.614256

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Copyright © 2020 Fagre, Manhard, Adams, Eckley, Zhan, Lewis, Rocha, Woods, Kuo, Liao, Li, Corper, Challa, Mount, Tumanut, Tjalkens, Aboellail, Fan and Schountz

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Monocytosis and histiocytic arteritis in SARS-CoV-2-infected and untreated hamsters. (A) Major branches of pulmonary artery contain numerous monocytes adhered to endothelial cells. (B) The luminal monocytes in pulmonary artery lumen (PAL) include multinucleate cells attached to the luminal surface of endothelium (red arrow) and the vessels is surrounded by many macrophages. (C) Close-up of pulmonary artery tunica intima showing endothelial-adherent monocytes some of which are subintimal (blue arrows) or migrating through the wall of the vessels, leukocyoclastic vasculitis. (D) Luminal monocytes and perivascular macrophages showing immunoreactivity against SARCoV-2 nucleocapsid. (E) Staining the vessels intima with endothelial marker, factor VIII show discontinuity of the tunical intima by migrating monocytes. (F) Most of the cells crowding tunica intima are showing strong immunoreactivity for the macrophage marker, CD204.