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. 2020 Dec 31;10:22436. doi: 10.1038/s41598-020-80288-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Distribution of NAT2 allele groups in two colorectal cancer cohorts. Genotyping of tumor and patient-matched normal samples identified three NAT2 allele groups encoding slow acetylator variants present in a (A) Finnish cohort of 1511 patients analyzed by SNP array genotyping and a (B) Swedish cohort of 56 patients analyzed by NGS sequencing. The allele NAT2*12 was detected in the cohort of Finnish colorectal cancers, but was excluded as its frequency was < 0.05. Percentages are calculated based on the total number of genotypes obtained for each patient group.