Table 1.

Distribution of NAT2 genotypes and LOH events identified in tumor/normal colorectal cancer pairs in (1) Finnish cohort, (2) Swedish cohort and (3) combined data.

NAT2 haplotype	Number of individuals			LOH events in intermediate acetylators			Cases where the *4 allele is lost
	(1)	(2)	(3)	(1)	(2)	(3)	(1)	(2)	(3)
Rapid acetylators
NAT2*4/*4	117	2	119	1	0	1	1	0	1
NAT2*4/*12A	2	0	2	2	0	2	1	0	1
Total	119	2	121	3	0	3	2	0	2
Intermediate acetylators
NAT2*4/*5A	20	1	21	4	0	4	2	0	2
NAT2*4/*5B	328	10	338	95	4	99	50	0	50
NAT2*4/*5C	16	1	17	6	1	7	3	1	4
NAT2*4/*6A	170	5	175	58	0	58	29	0	29
NAT2*4/*7B	30	1	31	11	0	11	8	0	8
Total	564	18	582	174	5	179	92	1	93
Slow acetylators
NAT2*5A/*5A	1	0	1	0	0	0	0	0	0
NAT2*5B/*5B	228	6	234	12	0	12	0	0	0
NAT2*5C/*5C	3	0	3	0	0	0	0	0	0
NAT2*5A/*5B	33	0	33	15	0	15	0	0	0
NAT2*5A/*5C	6	0	6	3	0	3	0	0	0
NAT2*5B/*5C	35	3	38	16	0	16	0	0	0
NAT2*5A/*6A	20	1	21	6	0	6	0	0	0
NAT2*5B/*6A	308	18	326	106	0	106	0	0	0
NAT2*5C/*6A	19	0	19	5	0	5	0	0	0
NAT2*5A/*7B	5	0	5	2	0	2	0	0	0
NAT2*5B/*7B	58	3	61	15	0	15	0	0	0
NAT2*5C/*7B	1	1	1	1	0	1	0	0	0
NAT2*6A/*6A	84	4	88	0	0	0	0	0	0
NAT2*6A/*7B	25	1	26	9	0	9	0	0	0
NAT2*7B/*7B	2	0	2	0	0	0	0	0	0
Total	828	36	864	190	0	190	0	0	0
Total patients	1511	56	1567	367	5	372	0	0	95

NAT2 acetylator phenotype was called based on rs1801279, rs1041983, rs1801280, rs1799929, rs144176822, rs1799930, rs1208, rs1799931, rs2552, rs4646247, rs971473, rs45547533, rs721398 and rs721399 genotypes.

Terms in bold refer to the acetylator phenotype of each tumor (rapid, intermediate or slow) given its NAT2 haplotype.