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. 2020 Dec 31;10:22443. doi: 10.1038/s41598-020-79882-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Genetic alterations in glycocalyx-related genes. (a,b) Screening of public exome sequencing data indicate somatic mutations and copy number alterations (CNAs) in tissues of melanoma (mela.) and bladder cancer (bladder). (a) Shown are the percentages of patients with genetic alterations in the proteoglycans syndecan 1 (SDC1), SDC2, SDC3 and SDC4, the heparan sulphate degrading heparanase (HPSE), exostosin glycosyltransferase 1 (EXT1) and EXT2. (b) Shown are the percentages of patients with genetic alterations in hyaluronidase 1 (HYAL1) and HYAL2 and hyaluronan synthases (HAS1), HAS2 and HAS3.