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Iron recycling in macrophages. Macrophages recover iron from phagocytized erythrocytes and heme from heme–HPX or HP–hemoglobin complexes after degradation by HMOX. Iron not used in the macrophage is stored in FN or exported to the circulation by FPN with CP's cooperation. Heme–HPX, heme–hemopexin; HP-Hb, haptoglobin–hemoglobin; HMOX, heme oxygenase; FPN, ferroportin; CP, ceruloplasmin; FN, ferritin; Tf, transferrin; Holo-Tf, holotransferrin; PCBP1, poly(rC)-binding protein 1.
