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. 2020 Dec 18;8:592833. doi: 10.3389/fbioe.2020.592833

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Copyright © 2020 Yang, Wang, Shi, Li, Gao, Yu, Liu, Zhang, Wang, Zhang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The wound healing process was significantly impaired in the diabetic state. (A–F) The diabetic wound manifests characteristics of impaired re-epithelialization (A), aberrant angiogenesis (B), and impaired collagen deposition (C,D) examined by Masson trichrome staining. Decreased extracellular matrix deposition (E,F) shown by H&E observation. (G,H) HIF-1α significantly decreased in diabetic wound. HIF-1α of normal and diabetic wounds was examined through immunohistochemistry. The collagen deposition density, extracellular matrix thickness, and HIF-1α positive area were calculated by ImageJ. Data are shown as mean ± SD. **p < 0.01, n = 3.