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. 2020 Dec 18;11:610688. doi: 10.3389/fimmu.2020.610688

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Copyright © 2020 Galipeau, Greig, Liu, Driedger and Langlois

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of antibody isotype characteristics and an approximate timeline from SARS-CoV-2 infection to possible immunity. Each antibody isotype is represented with their typical form and associated heavy chain. A brief description of their main function as well as a representation of upregulated and downregulated cytokine necessary for each class switching is also included. The approximate timeline of appearance and subsequent decrease of each isotype in relation to the viral RNA is shown. The curves and values are based on recent serological studies discussed in this review. Since limited literature is available on the implication of IgE in the pathogenesis and antibody mediated immunity to SARS-CoV-2, as such the representation of the IgE timeline is purely hypothetical. Figures were generated using (23).