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. 2020 Dec 18;14:617513. doi: 10.3389/fnins.2020.617513

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Copyright © 2020 Soto-Perez, Baumgartner and Kanadia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pairwise comparison of SMC and NUDE_C domain sequences in vertebrates. (A–D) Matrices showing the percentage homology in pairwise species comparisons of (A) the entire protein sequence of the respective NDE1 ortholog; (B) the SMC domain sequences; (C) the NUDE_C domain sequences; and (D) the stretch of sequence with high conservation observed in Figure 4, spanning the end of the SMC domain to the beginning of the NUDE_C domain (K106 to K185 in the human NDE1 sequence). Color corresponds to the degree of sequence homology. CR, conserved region.