Table 4.
Clinical profile, laboratory tests and bone parameters according ALS subtype.
| ALS Mean ± SD (95% CI) | |||
|---|---|---|---|
| Bulbar (N = 11) | Spinal (N = 22) | Mann-Whitney Z (p) | |
| Clinical profile | |||
| Time from diagnosis (months) | 29.3 ± 20.1 (13.8–44.7) | 22.0 ± 16.9 (14.5–29.4) | −1.071 (0.284) |
| ALSFRS-R score | 36.7 ± 6.5 (31.7–41.7) | 33.9 ± 9.9 (28.8–39.0) | −0.405 (0.685) |
| Barthel index | 94.0 ± 13.4 (77.3–110.6) | 68.1 ± 22.0 (54.7–81.3) | −2.265 (0.026)* |
| FEV% | 74.4 ± 13.6 (61.7–87.0) | 79.5 ± 14.7 (65.9–93.2) | −0.768 (0.442) |
| BMI | 24.2 ± 2.4 (22.5–25.9) | 24.7 ± 2.8 (23.4–25.9) | −0.569 (0.589) |
| Fat% | 15.1 ± 3.2 (11.7–18.4) | 19.4 ± 3.5 (17.4–21.3) | −2.180 (0.029)* |
| Muscle% | 39.9 ± 2.2 (37.6–42.2) | 35.6 ± 2.5 (34.2–37.1) | −2.725 (0.006)** |
| MRC global score | 73.0 ± 7.1 (65.5–80.4) | 52.3 ± 15.3 (43.8–60.8) | −2.618 (0.009)** |
| Laboratory test | |||
| 25-OH-VitD (ng/mL) | 27.3 ± 6.8 (16.4–38.2) | 17.4 ± 5.7 (10.4–24.5) | −1.715 (0.086) |
| Calcium (mg/dL) | 9.5 ± 0.4 (9.0–9.9) | 9.4 ± 0.2 (9.2–9.6) | −0.453 (0.662) |
| Alkaline phosphatase (UI/L) | 57.5 ± 9.6 (47.4–67.5) | 67.2 ± 24.1 (53.2–81.2) | −1.279 (0.201) |
| T4 (ng/dL) | 1.2 ± 0.2 (0.8–1.6) | 2.1 ± 2.6 (0.1–4.4) | −0.570 (0.575) |
| TSH (uU/mL) | 2.1 ± 0.4 (1.6–2.5) | 1.4 ± 0.6 (1.1–1.7) | −2.144 (0.032)* |
| Bone parameters | |||
| I-stiffness | 86.8 ± 33.7 (64.1–109.5) | 86.9 ± 30.1 (73.5–100.2) | −0.076 (0.939) |
| BUA (dB/MHz) | 115.4 ± 25.1 (98.5–132.4) | 113.1 ± 21.7 (103.5–122.8) | −0.229 (0.819) |
| SOS (m/s) | 1535.3 ± 63.2 (1492.9–1577.8) | 1541.8 ± 58.9 (1515.3–1568.0) | −0.496 (0.620) |
| T-score | −1.0 ± 2.6 (−2.7–0.7) | −1.0 ± 2.3 (−2.0–0.0) | −0.115 (0.909) |
| BMD (g/cm2) | 0.592 ± 0.226 (0.439–0.744) | 0.602 ± 0.205 (0.511–0.693) | −0.191 (0.849) |
*
p < 0.05;
**
p < 0.01.