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. 2020 Jul 2;35(8):1875–1888. doi: 10.1093/humrep/deaa111

Figure 2.

Figure 2.

Identification of interleukin-17 signalling pathway using RNA-seq analysis. (A) KEGG pathway enrichment analysis of DEGs between pregnant and not pregnant. Left panel: horizontal axis indicates −log10 (P-value) of the corresponding KEGG classification (left). Right panel shows 33 genes involved in 7 KEGG pathways outlined on the left; bars below the gene names indicates whether a gene is up-regulated (green) or down-regulated (red) in the not pregnant group. (B) IL-17A signalling pathway with DEGs outlined in red. More than one gene may be included in one node. Pathway components were extracted from the KEGG database (http://www.genome.jp/kegg/kegg1.html). (C) Box plots of the six DEGs associated with the IL-17 pathway from RNA-seq analysis. The not pregnant group is illustrated in blue and the pregnant group is illustrated in red. These six genes are up-regulated in the not pregnant group. KEGG, Kyoto Encyclopaedia of Genes and Genomes.