Table 1.
The clinical data and conventional MR imaging of non-functioning pituitary macroadenomas (NFPAs) with and without progression/recurrence (P/R).
| P/R | Non-P/R | p | |
|---|---|---|---|
| Number of patients | 28 | 22 | |
| Sex | 0.111 | ||
| Male | 19 (67.9%) | 10 (45.5%) | |
| Female | 9 (32.1%) | 12 (54.5%) | |
| Age (y) | 53.5 (44, 63) | 42 (23.5, 60.5) | 0.089 |
| Clinical symptoms | |||
| Visual disturbance | 26 (92.9%) | 13 (59.1%) | 0.006* |
| Headache | 8 (28.6%) | 11 (50%) | 0.121 |
| Symptoms of sex hormones (decreased libido, sexual dysfunction, and/or amenorrhea/oligomenorrhea) | 5 (17.9%) | 1 (4.5%) | 0.211 |
| Incidental | 2 (7.1%) | 4 (18.2%) | 0.385 |
| Hypopituitarism | 0.047* | ||
| No | 12 (42.9%) | 17 (77.3%) | |
| Single | 8 (28.6%) | 3 (13.6%) | |
| Multiple | 8 (28.6%) | 2 (9.1%) | |
| Hyperprolactinemia | 10 (35.7%) | 6 (27.3%) | 0.525 |
| Extent of surgical resection | 0.157 | ||
| Gross-total resection (GTR) | 3 (10.7%) | 6 (27.3%) | |
| Gross-total resection (STR) | 25 (89.3%) | 16 (72.7%) | |
| Successful chiasmatic decompression | 9 (32.1%) | 17 (77.3%) | 0.002* |
|
Cavernous sinus invasion
(Knosp classification) |
0.077 | ||
| Grade 1–2 | 18 (64.3%) | 19 (86.4%) | |
| Grade 3–4 | 10 (35.7%) | 3 (13.6%) | |
|
Extrasellar extension
(Hardy’s classification) |
0.045* | ||
| Grade 1–2 | 17 (60.7%) | 19 (86.4%) | |
| Grade 3–4 | 11 (39.3%) | 3 (13.6%) | |
| Compression of optic chiasm | 27 (96.4%) | 17 (77.3%) | 0.075 |
| Compression of the third ventricle | 21 (75%) | 9 (40.9%) | 0.015* |
| Hydrocephalus | 2 (7.1%) | 1 (4.5%) | 1 |
| Giant (>40 mm) | 9 (32.1%) | 2 (9.1%) | 0.085 |
| Maximum tumor height (mm) | 35.5 (27.5, 43.5) | 18 (10, 26) | <0.001* |
| Tumor volume (cm3) | 12.3 (4.4, 20.1) | 2.7 (1.2, 8) | <0.001* |
| SVM score | 0.999 (0.960, 1.040) | 0.030 (−0.241, 0.301) | <0.001* |
Continuous variables were presented as median and interquartile range (IQR).
*Statistical difference (p < 0.05).