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. 2020 Dec 3;11:602889. doi: 10.3389/fphar.2020.602889

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Copyright © 2020 Lv, Jiang, Yang, Zhang, Gao, Cao and Song

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of FGIN-1-27 on pigmentation in guinea-pig skin. (A) Representative photographs of dorsal skin of guinea pigs. (B) The degree of depigmentation was determined by a chromameter (CR-300; Minolta, Osaka, Japan) once a week for 4 weeks. The ΔL value was calculated using the L value (brightness index) measured with the chromameter follows: ΔL = L (at each week measured) − L (at day 0). Negative ΔL values indicate an UV-induced darkening of the skin. An increase in the ΔL value indicates a decrease in hyperpigmentation induced by UV. (C) Masson–Fontana ammoniacal silver staining of skin biopsies. (D) Immunohistochemical staining of skin biopsies for the detection of S-100 as a melanocyte marker protein (E) Number of melanocytes per microscopic field in skin sections. Bar = 50 μm *p < 0.05 vs. vehicle-treated groups.