TABLE 1.

Summary of key features of HTA agencies.

Jurisdiction	Regulatory approval	HTA assessment and appraisal	Main HTA criteria	Influence of HTA on drug pricing	Managed entry scheme
Australia	National	National	Clinical, cost effectiveness	Indirectly as it has an impact on ICER	Yes
Canada	National	National and regional	Clinical, cost effectiveness	Indirectly as it has an impact on ICER	Yes
England	Pan- European	National	Clinical, cost effectiveness	Indirectly as it has an impact on ICER	Yes
France		National	Clinical	Yes, ASMR rating used for pricing negotiation	Yes
Germany		National	Clinical	Indirectly through the level of added benefit	No
Italy		National and regional	Clinical, budget impact	Yes	Yes
Spain		National and regional	Clinical, budget impact	Yes	Yes

Notes: Allen et al. (2017) and Angelis et al. (2018).