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. 2020 Dec 18;7:581082. doi: 10.3389/fmed.2020.581082

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Copyright © 2020 Osuru, Paila, Ikeda, Zuo and Thiele.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of Sepsis with Isoflurane or Propofol anesthesia on Liver Oxidative stress markers. (A) Liver protein carbonyl content was increased in isoflurane sepsis (**p = 0.001) and unchanged (p = 0.511) in Propofol + Sepsis group. (B) Serum nitric oxide levels was significantly increased in both isoflurane sepsis (****p = 0.0001) and Propofol + Sepsis groups (***p = 0.0009). (C) S-nitrosylated protein levels was increased in Isoflurane +Sepsis group (*p = 0.043) and Propofol + Sepsis groups (*p = 0.014). (D) A representative immuno blots displaying total S- nitrosylated protein and total proteins (loading control) of Ponceau- S staining. n = 10–12 animals/group; Bars are mean ± S.D. “ns” (in graphs) represents not statistically significant.