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. 2020 Dec 18;7:581082. doi: 10.3389/fmed.2020.581082

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Copyright © 2020 Osuru, Paila, Ikeda, Zuo and Thiele.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mitochondrial DNA levels quantified with qPCR: Two Mitochondrial DNA encoded genes (Mt-Nd1 and Mt-Nd6) levels was normalized to a nuclear gene (Tubulin A1) and relative mtDNA levels was expressed as fold change to controls. Decreased mtDNA at gene Mt-Nd1 (p* = 0.040) and gene Mt-Nd6 (p** = 0.003) was observed in Isoflurane +Sepsis group compared to controls which had no sepsis. Interestingly, a small increase in mtDNA, Mt-Nd1 (p** = 0.007), and Mt-Nd6 (p** = 0.003) was seen in Propofol-sepsis group. n = 7–8 animals/group; Bars are mean ± S.D.