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. 2021 Jan 1;7(1):eabc7409. doi: 10.1126/sciadv.abc7409

Fig. 3. Nlrp3 deletion improves reproductive rate and autophagy pathway.

Fig. 3

Pregnancy rate (A) and mean litter size (B) in aged WT and Nlrp3−/− mice. Data are shown as means ± SD. ***P < 0.001, Nlrp3−/− versus WT mice; aaaP < 0.001, 4-month-old versus 12-month-old mice. (C) Western blot analysis with representative blot including BECLIN 1, ATG12, LC3, p62, BAX, and Bcl-2 levels in the ovary of 4- and 12-month-old WT and Nlrp3−/−. Densitometric analysis is shown as means ± SD, n = 10 mice per group and age. **P < 0.005 and ***P < 0.001; WT versus Nlrp3−/−; aaaP < 0.001, aaP < 0.01, aP < 0.05, young versus old mice.