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. 2021 Jan 1;7(1):eabc7409. doi: 10.1126/sciadv.abc7409

Fig. 5. NLRP3 pharmacological inhibition improves female fertility.

Fig. 5

(A) Body weight chart of 8-month-old female mice treated either with vehicle or MCC950. Mice were fed with the standard diet for 12 weeks, and their body weights were monitored weekly. Hormonal status in female mice given MCC950 treatment was determined by (B) AMH, (C) FSH, and (D) E2 serum levels in female compared with vehicle treated mice (E and F). N = 8 per group. Representative micrographs of vehicle and MCC950 ovarian sections and quantification of the number of ovarian follicles (PMF, PF, SF, and AF; and arrowhead, atretic follicle). N = 10 per group. Pregnancy rate (G) and mean litter size (H) in vehicle- and MCC950-treated mice. N = 15 per group. Data are presented as means ± SD. ***P < 0.001, **P < 0.01, *P < 0.05, MCC950-treated versus vehicle-treated mice.