Fig. 1. Acidic pH induces capsid opening and genome release of iflaviruses.

Cryo–electron micrographs of SBV (A and B), SBPV (C and D), and DWV (E and F). Virions at neutral pH (A, C, and E; the preparations also contain empty particles). Particles exposed to acidic pH (B, D, and F). Arrows indicate particles that remained in native conformation. Insets in (B), (D), and (F) show enlarged images of selected particles. Scale bar, 30 nm (F), 10 nm [inset in (F)].