Skip to main content
. 2021 Jan 1;7(1):eabe5575. doi: 10.1126/sciadv.abe5575

Fig. 5. Organization of the resolved N-linked glycans of SARS-CoV-2 S trimer.

Fig. 5

(A) Schematic representation of SARS-CoV-2 S glycoprotein. The positions of N-linked glycosylation sequons are shown as branches. A total of 18 N-linked glycans detected in our S-closed cryo-EM map are shown in red, and the remaining undetected ones in black. After ACE2 binding, the glycan density that appears weaker is indicated (*). (B) Surface representation of the glycosylated S trimer in the S-closed state with N-linked glycans shown in red. The location of glycan hole is indicated in black dotted ellipsoid, with the locations of S1/S2 and FP, and glycan at N657 site near the glycan hole indicated. The newly captured glycans at the N17 and N149 sites are indicated in the top view. (C) Surface representation of the glycosylated S-ACE2 complex with N-linked glycans in red.