Representative MRM chromatograms of genipin-1-gentiobioside, geniposide, genipin, shanzhiside and IS in rat plasma samples. (A) Blank plasma sample from a normal rat; (B) blank plasma sample from a rat exposed to isoflavones for 28 day; (C) blank plasma sample from a normal rat spiked with four analytes at LLOQ and IS; (D) plasma sample from a normal rat obtained at 0.5 h after oral administration of GF extract at a dose of 3.45 g/kg (37.85 ng/mL, 280.26 ng/mL, 676.35 ng/mL and 64.62 ng/mL for shanzhiside, genipin-1-gentiobioside, geniposide and genipin, respectively).