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. 2019 Nov 6;10(6):560–570. doi: 10.1016/j.jpha.2019.11.003

Fig. 2.

Fig. 2

Vac pretreatment decreases the bioavailability of AP and ratio of GSSG/GSH. (A) The serum concentrations of AP in SD rats at different time points (n = 4). (B) The activity of β-glucuronidase (β-GD) in cecum. n = 5 in Con or Vac group, and 10 in AP or Vac_AP group. (C and D) Hepatic GSSG/GSH and mRNA expression of genes (n = 6–8). (E and G) The hepatic protein levels of CYP3A4 and CYP2E1 (n = 6) as well as (F and H) enzymic activity of CYP1A2 and CYP2E1 measured with LC-MS/MS (n = 10 in Con or Vac group and 20 in AP or Vac_AP group). Data were mean ± S.E.M. *P < 0.05, **P < 0.01.