Table 8.
Pharmacokinetic parameters of cys after different routes of administration.
| Route of administration of cys | Cmax (mg/L) | Tmax (min) | t1/2 (min) | AUC0-∞ (mg･min/L) | CL (L/min) | Refs. | |
|---|---|---|---|---|---|---|---|
| Oral (450 mg cy) | 2.86 | 72 | 222 | 9.62 | 1.5 | [87] | |
| Gastro-intestinal (500 mg cy) | Stomach | 8.8 | 50 | 94.5 | 880 | N.D. | [88] |
| Small intestine | 11 | 21 | 112 | 983 | N.D. | ||
| Caecum | 5.2 | 64 | 98 | 713 | N.D. | ||
| Mid-ileum | 11 | 30 | 124 | 1034 | N.D. | ||
cys: cysteamine, Cmax: maximum concentration, Tmax: the time to reach Cmax, t1/2: half-life, AUC0-∞: the area under the curve between time 0 and the last sample, CL: clearance, N.D.: not determined.