Figure 2. ERBB2 plays an important role in cells expressing EGFR L861Q.

(A) Ba/F3 cells stably expressing the indicated cDNAs were cultured without IL-3 and counted daily. Data are representative of three independent experiments conducted with duplicate determinations (mean ± SE). (B) Lysates were extracted from 3T3 cells stably expressing the indicated cDNAs and subjected to western blot analysis. (C) Cells were serum-starved for 6 h, lysed, and then probed by western blot. (D) Isogenic stable cell lines were serum-starved for 6 h, lysed, and subjected to co-immunoprecipitation followed by western blot analysis. (E) HBECp53 cells were transfected with the construct indicated and incubated for 48 h after which lysates were extracted and subjected to western blot analysis.