Table 1.
Baseline (pre-treatment) five-minute means of heart rate variability and cardiac repolarization.
| Domain | Parameter | Unit | Base |
0hr |
3hr |
|||
|---|---|---|---|---|---|---|---|---|
| na | value* | na | value* | na | value* | |||
| HRV, Freq. | VLF | ms2 | 253 | 2829 ± 3372 (65, 26186) | 253 | 4214 ± 5976 (208, 49720) | 253 | 3386 ± 4710 (164, 40928) |
| LFn | n.u. | 272 | 0.61 ± 0.17 (0.09, 0.90) | 272 | 0.57 ± 0.17 (0.11, 0.89) | 272 | 0.60 ± 0.17 (0.13, 0.89) | |
| HFn | n.u | 272 | 0.39 ± 0.17 (0.10, 0.91) | 272 | 0.43 ± 0.17 (0.11, 0.89) | 272 | 0.40 ± 0.17 (0.11, 0.87) | |
| LFHFR | 1:1 | 272 | 2.13 ± 1.61 (0.10, 8.80) | 272 | 1.73 ± 1.25 (0.12, 8.38) | 272 | 2.07 ± 1.49 (0.15, 8.02) | |
| HRV, Time | SDNN | ms | 272 | 78.1 ± 38.3 (15, 265) | 272 | 92.3 ± 43.8 (24, 270) | 272 | 82.0 ± 38.7 (23, 243) |
| RMSSD | ms | 272 | 61.3 ± 43.8 (9, 280) | 272 | 78.3 ± 47.6 (16, 285) | 272 | 63.6 ± 40.8 (14, 267) | |
| pNN50 | % | 272 | 28.2 ± 22.3 (0, 74) | 272 | 37.3 ± 22.4 (0, 79) | 272 | 30.5 ± 22.9 (0, 80) | |
| Cardiac repolar. | QTc | ms | 272 | 417.3 ± 19.7 (376.0, 471.1) | 272 | 416.3 ± 20.6 (378.5, 482.2) | 272 | 418.2 ± 20.2 (379.4, 482.9) |
| P-comp. | (unitless) | 272 | 0.20 ± 0.10 (0.07, 0.73) | 272 | 0.02 ± 0.11 (0.04, 0.78) | 272 | 0.20 ± 0.12 (0.07, 0.82) | |
| QRS-comp. | (unitless) | 272 | 0.45 ± 0.18 (0.08, 1.05) | 272 | 0.46 ± 0.18 (0.09, 1.01) | 272 | 0.45 ± 0.18 (0.09, 1.17) | |
| T-comp. | (unitless) | 272 | 0.12 ± 0.05 (0.01, 0.38) | 272 | 0.11 ± 0.05 (0.02, 0.30) | 272 | 0.12 ± 0.05 (0.02, 0.33) | |
Abbreviations: S.D. = Standard deviation; n.u. = normalized units; VLF = Very low frequency (Power in range 0.0033–0.04 Hz); LFn = Low frequency (Power in range 0.04–0.15 Hz), corrected for heart rate; HFn = High frequency (Power in HF range 0.15–0.4 Hz), corrected for heart rate; LFHFR = Ratio of LF over HF; SDNN = Standard deviation of the duration of all NN intervals; RMSSD = Square root of the mean of the squares of the differences between adjacent NN intervals; pNN50 = Percent of consecutive NN intervals that differ by more than 50 ms; QTc = Interval of time between Q and T interval, corrected for heart rate; P-comp. = P-complexity (representing P-wave/atrial depolarization); QRS-comp. = QRS-complexity (representing QRS-wave/ventricular depolarization); T-comp. = T-complexity (representing T-wave/ventricular repolarization).
The sample size (n) shown here is discrepant from the 288 expected (of 48 participants completing 6 treatments): while a total of 48 participants were included in analyses, not all participants could complete all treatments or had data available for all time-points – some treatments or time-points were missed due to participant absence or technical difficulties and the inability to reschedule repeats within the study period.
Values are presented as mean (standard deviation [minimum.,maximum]).