Figure 4.

PRM-based validation of candidate proteins by parallel reaction monitoring. The length of the box is thus the interquartile range of the sample. The other dimension of the box does not represent anything in particular. A line is drawn across the box at the sample median. Whiskers sprout from the two ends of the box until they reach the sample maximum and minimum. The crossbar at the far end of each whisker is optional and its length signifies nothing.: (A) Chromogranin A (CHGA); quantification shown in box plot with significant change with P value P < 0.0001 and ROC curve (B) Inner Membrane Mitochondrial Protein (IMMT); quantification shown in box plot with significant change with P value P < 0.0075 and ROC curve (C) Ras-related protein Ral-A (RalA); quantification shown in box plot with significant change with P value P < 0.04 and ROC curve