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. 2020 Dec 9;5(12):1210–1224. doi: 10.1016/j.jacbts.2020.09.013

Figure 4.

Figure 4

Nlrp3−/− Bone Marrow Chimeras Have Improved Survival and Less Detrimental Remodeling Post-MI

(A) Mortality rates in WT and Nlrp3−/− bone marrow chimeric mice up to 21 days after MI (p < 0.001, by Kaplan-Meier analysis with log-rank test; n = 19 WT, n = 23 Nlrp3−/−). (B) Left ventricle (LV) infarct size measured by picrosirius red staining (n = 9 WT, n = 22 Nlrp3−/−) and (C) ejection fraction and interventricular septum (IVS) thickness in diastole (d) and systole (s) adjusted for tibia length (TL) measured 21 days post-MI by echocardiography (n = 9 WT, n = 23 Nlrp3−/−). (D) LV tissue Nppa mRNA levels measured by real-time quantitative polymerase chain reaction. (E) mRNA levels of several genes measured by real-time quantitative polymerase chain reaction, in the viable and infarcted LV tissue collected 21 days post-MI in chimera mice (n = 9 WT, n = 23 Nlrp3−/−). (F)Nlrp3−/− mRNA levels in viable and infarcted LV tissue 21 days post-MI in chimera mice (n = 9 WT, n = 23 Nlrp3−/−). Values are presented as mean ± SEM. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001. Abbreviations as in Figure 1.