Figure 2.

Hierarchical Clustering Heat Map of Clinically Relevant Metabolites/Lipids in AV Leaflets

Heat map showing differential metabolite/lipid abundance levels across different grades of stenotic severity as determined by AVA (N = 62) (A), MPG (N = 28) (B), and C-score (N = 19) (C). Rows indicate metabolites/lipids; columns indicate disease severity. Color code indicates compound abundance.∗Compounds that were identified by all 3 different ways of determining stenotic severity (AVA, MPG, and C-score). N = number of differential metabolites/lipids across different grades of stenotic severity. AV = aortic valve; other abbreviations as in Figure 1.