Figure 3.

Metabolomics Pathway Analysis

“Metabolome view” from pathway analysis showing the altered metabolic pathways that are representative of differential metabolites/lipids (N) as determined by MPG (N = 28) (A), AVA (N = 62) (B), C-score (N = 19) (C), and by combining MPG, AVA, and C-score (N = 72) (D). Each circle represents a pathway, and the size and color of each circle was based on pathway impact value and significance, with red being most significantly associated with stenotic severity. N = number of differential metabolites/lipids across different grades of stenotic severity. The p value was calculated from the enrichment analysis, and the impact value was calculated from pathway topology analysis. Abbreviations as in Figure 1.