Figure 4.
Metabolite-Clinical Parameter and Metabolite-Metabolite Correlation Analysis
(A) Differential metabolites/lipids were correlated with clinical parameters. Positive correlations are displayed in purple and negative correlations in orange. Color intensity and size of the circle are proportional to the correlation coefficients (Spearman correlation). In this correlogram, correlations with p > 0.05 are considered insignificant and are left blank. Only those metabolites or lipids (27) having more than 1 significant correlation (p < 0.05) with any of the 3 hemodynamic parameters—peak aortic jet velocity (Vmax), MPG, and AVA—were used to construct the correlogram. (B) Network plot highlighting the highly correlated metabolites/lipids. The nodes represent compounds, and the edges represent biochemical reactions. The thickness of the edges represents the strength of the correlations. The connections between the nodes were established by Pearson correlation (|rp| > 0.8). Positive correlations are displayed in pink and negative correlations in violet. APGR = Ala-Pro-Gly-Pro-Arg; HDL = high-density lipoprotein; LDL = low-density lipoprotein; LysoPA = lysophosphatidic acid; LysoPE = lysophosphatidylethanolamine; MG = monoglyceride; PC = phosphatidylcholine; PI = Phosphatidylinositol; TA-ga = Tetrahydroaldosterone-3-glucuronide; TG = triglyceride; other abbreviations as in Figure 1.